Taking place in 2024, Modern Warfare II follows the story of the MW reboot, featuring returning characters from Task Force 141 and the Urzikstan Liberation Force leader Farah Karim. Al-Qatala is still a threat, but all eyes are on Quds Force, an Iranian revolutionary group commanded by Hassan Zyani.

The story takes place in the year of 2011 when a radical leader has executed the president of an unnamed country in the Middle East, and an ultranationalist movement ignites a civil war in Russia.